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Secondly, the decreasing insulin 1/2 (INS1/2) transcription and the smaller insulin-secreting vesicles are observed after the upregulation of THADA, together leading to the impaired insulin secretion
262,263 Although oligodendrocyte pathology is extensively explored in demyelinating disorders, accumulating evidence suggests its involvement in the pathogenesis of neurodegenerative diseases, including AD, 110 PD, 86 ALS, 89 and HD
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